Revista médica de Chile
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Revista médica de Chile · Sep 2021
Observational Study[Risk factors for adverse drug reactions in patients admitted to intensive care units].
Patients hospitalized in intensive care units (ICU) are at higher risk of having adverse drug reactions (ADR). ⋯ The identified risk factors have a great impact on pharmacokinetic and pharmacodynamic parameters, and should be considered to avoid the appearance of ADR.
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Revista médica de Chile · Sep 2021
[Intensive chemotherapy with tyrosine kinase inhibitors in philadelphia-positive acute lymphoblastic leukemia].
Before the advent of tyrosine kinase inhibitors (TKIs), patients with Philadelphia-positive Acute Lymphoblastic Leukemia (Ph+ALL) had a poor prognosis. The association of TKIs to intensive chemotherapy (CT) improved outcome. ⋯ The prognosis of Ph+ALL improved with the association of imatinib to intensive CT. MRD-negative status before three months in this series was not significantly associated with better outcomes. Our series suggests that the Ph+ALL national protocol associated to TKI is a therapeutic alternative with high CR and aceptable MRD (-) rates.
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Revista médica de Chile · Sep 2021
[Identification of genetic variants associated with familial hypercholesterolemia in Chilean children and adolescents].
Familial hypercholesterolemia (FH) is commonly associated with mutations in-LDL receptor (LDLR), apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9). ⋯ Children and adolescents carrying mutations associated with FH were found by selective screening, which constitutes the first stage in the identification of genetic variants in our country.
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Revista médica de Chile · Sep 2021
[Yield of two mortality predictors in immunocompetent patients with community acquired pneumonia].
The severity of community acquired pneumonia (CAP) can be evaluated by the PSI and CURB-65 scales. However, it is unknown whether their predictive capacity varies according to the etiology of the disease. ⋯ The prognostic performance of PSI in CAP varies according to the causative agent in adults. It is higher in non-severe bacterial cases, and superior to CURB-65.
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Revista médica de Chile · Sep 2021
[Quality of life of older people with depression and dependence: validity of the SF-12 (short form health survey) questionnaire].
Depression and dependence have a great impact on the quality of life of older people. ⋯ The validity of the SF-12 for measuring HRQoL was demonstrated. People with depression and dependence have a worse physical and mental quality of life.