Mayo Clinic proceedings
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Mayo Clinic proceedings · Feb 2021
The Association Between the Use of Cholinesterase Inhibitors and Cardiovascular Events Among Older Patients With Alzheimer Disease.
To evaluate the association between the use of cholinesterase inhibitors (ChEIs) and incident cardiovascular events (CVEs) among older patients with Alzheimer disease (AD). ⋯ The use of ChEIs was associated with a decreased risk of incident CVEs among patients with AD. The cardioprotective effect of ChEIs showed a dose-response relationship.
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Mayo Clinic proceedings · Feb 2021
Comparative StudyAge-Stratified Sex-Related Differences in the Incidence, Management, and Outcomes of Acute Myocardial Infarction.
To assess the impact of female sex on the incidence, management, and outcomes of myocardial infarction (MI) in different age groups. ⋯ Compared with men, women have lower incidence of MI and less likelihood of undergoing invasive treatment regardless of age. However, post-MI outcomes are age specific. The negative impact of female sex on most outcomes was most pronounced in young and middle-aged women.
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To assess the prevalence of coagulation abnormalities in patients with systemic light chain (AL) amyloidosis and their association with disease-related characteristics, disease progression, and survival. ⋯ Coagulation abnormalities occur in a significant proportion of patients with AL amyloidosis and are associated with advanced disease and inferior outcomes. Larger studies are needed to establish whether a relationship exists between treatment response and improvement in individual parameters.
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Mayo Clinic proceedings · Feb 2021
Host Factors and Outcomes in Hospitalizations for Pneumocystis Jirovecii Pneumonia in the United States.
To assess host factors in pneumocystis jirovecii pneumonia (PCP)-related hospitalizations and compare outcomes between HIV and non-HIV patients. ⋯ The epidemiology of PCP has shifted with an increase in the prevalence of non-HIV patients who have higher intubation rates and prolonged hospitalizations compared with matched HIV patients.