Mayo Clinic proceedings
-
Mayo Clinic proceedings · Mar 2013
Comparative Study Clinical TrialCombined use of the novel biomarkers high-sensitivity troponin T and ST2 for heart failure risk stratification vs conventional assessment.
To assess an innovative multimarker strategy for risk stratification of death in a real-life ambulatory heart failure (HF) cohort. ⋯ A multimarker strategy seems useful for stratifying risk in chronic HF. However, NT-proBNP in addition to the new-generation biomarkers hs-cTnT and hs-ST2 had a limited effect on risk stratification.
-
Mayo Clinic proceedings · Mar 2013
Randomized Controlled TrialLosartan added to β-blockade therapy for aortic root dilation in Marfan syndrome: a randomized, open-label pilot study.
To assess the tolerability and efficacy of the investigational use of the angiotensin II receptor blocker losartan added to β-blockade (BB) to prevent progressive aortic root dilation in patients with Marfan syndrome (MFS). ⋯ This randomized, open-label, active controlled trial mostly based on a pediatric population demonstrated for the first time that losartan add-on BB therapy is safe and provides more effective protection to slow the progression of aortic root dilation than does BB treatment alone in patients with MFS.