Surgery, gynecology & obstetrics
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Surg Gynecol Obstet · Jan 1987
Skin microvascular permeability after resuscitation with Ringer's lactate solution from endotoxin shock.
Skin microvascular membrane permeability was assessed in anesthetized dogs after resuscitation from endotoxin shock. Infusion of Ringer's lactate solution, in a volume equal to 7 per cent of the body weight, reversed hypotension produced by an intravenous injection of Escherichia coli endotoxin (0.5 milligrams per kilogram). The shock group was compared with a group of dogs not given endotoxin and infused with a similar dose of Ringer's lactate solution and a with control group of dogs. ⋯ The wet to dry tissue weight ratio of skin samples did not increase in the endotoxin group. Skin microvascular membrane permeability did not increase. The safety factors that helped to prevent edema after infusion of Ringer's lactate solution included an increase in lymph flow and sieving by the intact microvascular membrane which diluted the interstitial protein concentration.