Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
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Zhonghua Shao Shang Za Zhi · Feb 2018
[Interventional effects of BAY11-7082 on lung inflammatory response at the early stage and acute lung injury of rats with severe burns].
Objective: To investigate the interventional effects of BAY11-7082 on lung inflammatory response at the early stage and acute lung injury of rats with severe burns. Methods: (1) Experiment 1. Twelve Sprague-Dawley (SD) rats were divided into control (C) group and burn (B) group according to the random number table, with 3 rats in group C and 9 rats in group B. ⋯ At PIH 24, the mRNA expressions of IL-1β, IL-18, NLRP3, and caspase-1 in lung tissue of rats in group SB were 5.0±0.4, 3.32±0.21, 3.54±0.42, and 6.3±1.0, respectively, significantly higher than 1.0, 1.00, 1.00, and 1.0 of group C (t=13.97, 14.14, 11.78, 7.13, P<0.01). The mRNA expressions of IL-1β, IL-18, NLRP3, and caspase-1 in lung tissue of rats in group BI were 2.6±0.5, 2.00±0.28, 1.39±0.21, and 2.5±0.5, respectively, significantly lower than those of group SB (t=7.11, 5.80, 9.99, 4.65, P<0.05 or P<0.01). Conclusions: Applying BAY11-7082 at the early stage of acute lung injury of rats with severe burn can reduce the expression of caspase-1, decrease the levels of IL-1β and IL-18, and decrease the MPO content of lung tissue and the total protein content of BALF through inhibiting NLRP3, thus alleviating the lung inflammatory response and lung injury.
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Zhonghua Shao Shang Za Zhi · Feb 2018
[Regenerative rehabilitation medicine: new requirement, new fusion and new direction].
Regenerative rehabilitation medicine is not just the combination of two disciplines of regenerative medicine and rehabilitation medicine but the new fusion of two disciplines, and it represents the development direction of regenerative medicine and rehabilitation medicine. With the improvement of people's demands for tissue injury or disease recovery, new technology and means should be required, and regenerative rehabilitation medicine will emerge and develop rapidly. It will play a key role in repair, regeneration and rehabilitation of diseases or injuries in patients.