Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
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Zhonghua Shao Shang Za Zhi · Aug 2008
[Discussion on the fluid resuscitation and monitoring during burn shock period].
The index of monitoring burn shock resuscitation includes clinical signs and symptoms, laboratory examinations, hemodynamic variables. In recent years, there exists a tendency that the amount of transfused fluid for burn shock resuscitation is notably increased and complications of some cases, such as abdominal compartment syndrome have been reported. ⋯ Instead of hemodynamic variables, urinary output combined with other traditional variables still should be considered primary criteria of adequate fluid therapy. Specification of the variables of monitoring burn shock resuscitation is also the basis to revise and optimize the fluid resuscitation formula.
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Zhonghua Shao Shang Za Zhi · Aug 2008
[Study on activation of mitogen-activated protein kinase pathway in lung tissue of rats with smoke inhalation injury].
To investigate the activation of mitogen-activated protein kinase (MAPK) pathway and the expression of inflammatory cytokine in lung tissue of rats with smoke inhalation injury, and to explore the injury mechanism. ⋯ The obvious inflammatory response in lung tissue can be induced by the poisonous gas released from the combustion of nonmetal materials in airtight cabin, and activate the expression of kinases in MAPK pathway, which may be one of mechanisms for lung injury induced by poisonous gas.
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Improvement in early burn treatment has been realized, the mortality of burn shock has been decreased. However, the treatment of burn shock is still inadequate and occult hypoperfusion is usually occurred. This may be difficult to identify the appropriate resuscitation endpoint. ⋯ Traditional endpoints, such as blood pressure, urine output are useful in managing mild and moderate burn shock. Additional endpoints that evaluate the adequacy of global and regional perfusion and oxygenation at the tissue level should be used in treatment of severe burn injury. Now the most useful parameters may be blood pressure, urine output, serum lactate, BE and CVP, SCVO2.
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Zhonghua Shao Shang Za Zhi · Aug 2008
[Study on crosstalk between phosphatidylinositol 3 -kinase/Akt pathway and p38 mitogen-activated protein kinase pathway in cardiomyocyte with challenge of burn serum].
To investigate the possibility of crosstalk between phosphatidylinositol 3-kinase (PI3-K)/Akt pathway and p38 mitogen-activated protein kinase (p38MAPK) pathway in cardiomyocyte with challenge of burn serum, and to explore their influence on cardiomyocyte injury after burn. ⋯ There is being crosstalk between PI3K/Akt pathway and p38 MAPK pathway in cardiomyocytes with challenge of burn serum, which may regulate cardiomyocytes.
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Zhonghua Shao Shang Za Zhi · Jun 2008
[Investigation of life quality of severe burn patients at rehabilitation stage and analysis of the related influential factors].
To investigate the life quality in severe burn patients at rehabilitation stage and analysis of related influential factors. ⋯ The life quality level of severe burn patients at rehabilitation stage is low. Social support, return to work, duration after burn, occupation and deep burn area are correlating factors affecting life quality. Rehabilitation;