Journal of Korean Neurosurgical Society
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J Korean Neurosurg Soc · Feb 2011
Case ReportsVasogenic edema of the Basal Ganglia after intra-arterial administration of nimodipine for treatment of vasospasm.
The intra-arterial administration of nimodipine (IAN) is commonly used for cerebral vasospasm refractory to medical treatments. We report two cases of vasogenic edema after IAN. ⋯ Consequently, vasogenic edema developed in the basal ganglia. Reperfusion following IAN for vasospasm may have the potential for inciting vasogenic edema in the ischemic brain.
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J Korean Neurosurg Soc · Feb 2011
The effect of minocycline on motor neuron recovery and neuropathic pain in a rat model of spinal cord injury.
Minocycline, a second-generation tetracycline-class antibiotic, has been well established to exert a neuroprotective effect in animal models and neurodegenerative disease through the inhibition of microglia. Here, we investigated the effects of minocycline on motor recovery and neuropathic pain in a rat model of spinal cord injury. ⋯ By inhibiting microglia and astrocyte activation, minocycline may facilitate motor recovery and attenuate mechanical hyperalgesia in individuals with spinal cord injuries.