The Journal of infectious diseases
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Randomized Controlled Trial
Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.
Cytokines are key regulators of measles vaccine humoral and cellular immunity. Single-nucleotide polymorphisms (SNPs) that are associated with differences in cytokine levels should also influence measles vaccine-induced immunity. ⋯ Specific SNPs in the cytokine and cytokine receptor genes are significantly associated with variations in measures of the immune response to measles vaccination. These results need to be further validated in a larger cohort.