Comprehensive therapy
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Until recently, military personnel have had the greatest risk for cold injuries. During the past two decades, however, destitute persons without adequate clothing or shelter, and sports enthusiasts participating in snowmobiling, mountain climbing, and skiing have been responsible for the increased incidence of cold exposure seen in a large civilian population. Consequently, cold injury remains a crippling problem. Although research is opening new avenues of accurate diagnosis and expeditious treatment, the standard against which these methods must be measured continues to be a rational treatment plan that often prevents the sequelae of cold injuries.
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The last ten years have been a period of extensive research and development of new agents for the treatment of cardiac rhythm abnormalities. Several new subclass Ic agents have been developed, and more recently the class III agents have become the focus of attention. These new agents are all remarkable for their potency and potential for producing side effects. While none of these agents offers the perfect cure for the treatment or prevention of cardiac arrhythmias, they all offer advantages and options that are valuable for clinical management of patients.