Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
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Zhongguo Zhong Yao Za Zhi · Sep 2020
[Pharmacovigilance of traditional Chinese medicine according to theory of preventive treatment of disease].
"Preventive treatment of disease" is one of the characteristics and advantages of traditional Chinese medicine. It is the most influential theory of traditional Chinese medicine. The core of the theory is "pre-prevention before disease", "prevention of disease from progress" and "prevention of recovery after disease", and the prevention concepts are "prevention of disease from deve-lopment" and "blockage and reversal". ⋯ This article intends to consider the theory and practice of pharmacovigilance of Chinese medicine from the "preventive treatment of disease", in order to provide reference for clinical safety medication. It has puts forward the practical measures of pharmacovigilance of traditional Chinese medicine, such as giving medical advice, paying attention to monitoring, preventing biological change, planning for the long term, preventing disease from changing, delaying the disease progress, protecting vital Qi, controlling internal disorder and preventing recurrence. It also indicated that pharmacovigilance of traditional Chinese medicine is an important part of the "preventive treatment of disease", and an important guarantee for the safe and rational use of medicines in clinical practice, which is conducive to protecting and promoting people's health and improving people's quality of life.
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Zhongguo Zhong Yao Za Zhi · Sep 2020
[Identification of quality markers for Pudilan Xiaoyan Oral Liquid].
On the basis of anti-inflammatory activity, combined with multiple indicators, the quality markers of Pudilan Xiaoyan Oral Liquid were screened and determined for quality control. Lipopolysaccharide(LPS) was used to induce normal human bronchial epithelial cell(NHBE) inflammation model. The anti-inflammatory effects of the main chemical components in Pudilan Xiaoyan Oral Liquid were examined one by one, and the pharmacodynamic basis for the overall anti-inflammatory efficacy of Pudilan Xiaoyan Oral Liquid was clarified to identify the quality markers of Pudilan Xiaoyan Oral Liquid and the contents of the quality markers were determined by high performance liquid chromatography(HPLC). ⋯ Considering the factors such as the IC_(50) value of each monomer component and the comprehensiveness of the quality control components, we proposed to use adenosine, cichoric acid, corynoline, baicalin and wogonin as quality markers of Pudilan Xiaoyan Oral Liquid. The contents of the five components were determined by HPLC, and the results showed that they were relatively stable in three batches of Pudilan Xiaoyan Oral Liquid. In this study, the quality control components selected by the anti-inflammatory activity test have a clear material basis, covering all four active pharmaceutical ingredients, which can fully reflect the quality of Pudilan Xiaoyan Oral Liquid, and effectively improve the quality control standard of Pudilan Xiaoyan Oral Liquid.
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Zhongguo Zhong Yao Za Zhi · Sep 2020
[Variety and standard arrangement of Yao medicine in Euphorbiaceae].
The names, basic sources, medicinal parts, efficacy and standards of the medicinal materials in Euphorbiaceae were systematically collated and analyzed by the textual research for Yao medicine monographs in this paper. The results showed that there were great differences in the names, basic sources, medicinal parts and efficacy of some medicinal materials recorded in different literatures. There were 19 genera and 60 species(including varieties) of Euphorbiaceae of Yao medicine, involving 50 kinds of medicinal materials. ⋯ The Yao medicine in Euphorbiaceae could be named by means of transliteration of Yao language/Yao language transliteration/Chinese medicine name, Laoban medicine, plant morphology, medicinal properties, color and smell of medicine, while the medicinal parts and efficacy of the same medicinal name were different from those of traditional Chinese medicine. Therefore, the name and basic sources of the medicinal materials in Euphorbiaceae were not standardized, and the quality standard is not perfect. The above results provided a reference for the construction and improvement of quality standard system, the promotion of the production of medicinal materials and clinical medication standards, and the further development and utilization of Euphorbiaceae.