Zhonghua nei ke za zhi
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Zhonghua nei ke za zhi · Oct 2009
[The changes and significance of interleukin-16 and CXC chemokine receptor 3 expression in pulmonary artery of smokers with chronic obstructive pulmonary disease].
To study the pathological characteristics of interleukin-16 (IL-16) and CXC chemokine receptor 3(CXCR3) in pulmonary artery of smokers with normal lung function and smokers with chronic obstructive pulmonary disease (COPD). ⋯ (1) Both in group S and group COPD, IL-16 and CXCR3 were mainly expressed in lymphocytes which were correlated with CD(8)(+)T-lymphocytes infiltrating the muscularized arteries. There were some suggestion that IL-16 probably recruited CD(8)(+)T-lymphocytes into muscularized arteries by enhancing the expression of CXCR3. (2) The intensity of IL-16 and CXCR3 were correlated with the index of clinical and pulmonary function that suggested pulmonary arterial inflammation might be one of the key factors associated with the progression of COPD, and inhibiting the pulmonary artery inflammation played an important role in prevention and cure of COPD.