Scandinavian journal of gastroenterology. Supplement
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Scand. J. Gastroenterol. Suppl. · Jun 1981
Comparative StudyThe new histamine H2-receptor antagonist ranitidine. Duration of action.
The antisecretory effects of a new histamine H2-receptor antagonist ranitidine hydrochloride 150 mg, have been tested on basal and pentagastrin-stimulated acid secretion in healthy volunteers 5 and 10 h after oral administration. In addition, the 24 h intragastric pH-profiles have been measured in patients undergoing parenteral nutrition after three oral doses of ranitidine 150 mg per day. ⋯ The intragastric pH remained above 5 for at least 24 h. Ranitidine has proven to be a more potent and longer acting antisecretory compound than cimetidine.
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Scand. J. Gastroenterol. Suppl. · Jan 1981
Inhibition of experimental stress ulcer formation in rats.
We present an operation model in rats, which according to our opinion prevents duodenogastric reflux effectively. The duodenum is divided distally from the pylorus and a pyloro-jejunostomy performed combined with a Roux-en-Y anastomosis. Rats operated this way and submitted to restraint stress developed significantly less stress lesions than operated control under same conditions. However, operated rats submitted to the operation and offered a 5 mMol/l drinking solution of crude taurocholic acid during 20 days before submitted to stress had significantly more stress lesions than operated animals with tap water before restraint stress.
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Scand. J. Gastroenterol. Suppl. · Jan 1981
The role of taurocholic acid, glycocholic acid and lysolecithin in experimental stress ulcer in the rat.
The stress ulcer formation is enhanced significantly in rats operated with pyloro-jejunostomy and Roux-en-Y anastomosis by taurocholic acid or a mixture of taurocholic and glycocholic acid. However, the incidence of stress ulcers is significantly reduced by adding lysolecithin to the drinking solution containing these bile acids in the same concentration, though lysolecithin alone induces significantly more stress ulcers than tap water in rats with the same operation submitted to immobilisation stress.
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Scand. J. Gastroenterol. Suppl. · Jan 1979
Majority and minority cell populations in GEP and bronchial endocrine tumours.
Gastro-entero-pancreatic (GEP) and bronchial endocrine tumours have been studied by immunohistochemistry using specific antisera against a variety of hormonal and neuronal peptides. In gastrinomas numerous tumour cells were found to contain GH-like immunoreactivity. These cells were identical with those storing gastrin. ⋯ One intestinal somatostatinoma contained gastrin cells as a minority cell population. Bronchial endocrine tumours contained scattered cells displaying ACTH-like or enkephalin-like immunoreactivity. Two such tumours in addition contained cells displaying neurophysin immunoreactivity.