Neurochirurgia
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Comparative Study Clinical Trial Controlled Clinical Trial
[Influence of sorbitol and mannitol on intracranial pressure (author's transl)].
The intracranial pressure was measured by an intraventricular catheter in 53 patients, in the course of 156 infusions of 40% Sorbitol and 72 infusions of 20% Mannitol. The amounts given and the rate of infusion were varied. ⋯ After Sorbitol the influence on lowering the pressure was more marked and longer lasting than after injections of Mannitol. As a possible treatment for raised intracranial pressure one may conclude that small amounts given over a shorter time (50-80 ml/5 min) produce the most favourable effect.