Infusionstherapie und klinische Ernährung
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Infusionsther Klin Ernahr · Apr 1978
Letter[Reply to W. L. Thompson's commentary (Infusionstherapie 4:56-62 1977) on G. Lindblad's and J. Falk's study on "Course of hydroxyethyl starch and dextran concentration in blood and liver of rabbits and the histopathological consequences of hydroxyethyl starch storage (Infusionstherapie 3:301-3 1976)].
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Infusionsther Klin Ernahr · Feb 1977
[Preoperative infusion therapy in childhood. I. Initial conditions and principles].
Infusion therapy for purposes of surgery differs significantly from the infusion requirements for "conservative" purposes, in adults as well as in infants and children. The preoperative situation of infants and children undergoing usual surgical procedures is particularly characterized by 1. the physiological conditions of the water-, electrolyte- and acid-base-balances; 2. the effects of the preoperative food-and fluid-restrictions; 3. the intraoperative fluid- and volumen-losses; 4. the combination between 1--3 and the postoperative food- and fluid-restriction and the postoperative metabolic conditions respectively. The problems, summarized under 1--4, have been discussed within this article. Further two papers will deal with studies on the use of "basic solutions" for the substitution of fluid- and electrolyte losses in pediatric surgery.
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Infusionsther Klin Ernahr · Aug 1976
[Blood regeneration after blood substitution with dextran 60 or hydroxyethyl starch of an identical volume].
Male rats of the Wistar strain survived an isovolaemic blood volume replacement down to a haematocrit value of 20% using commercial dextran 60 or hydroxyethyl starch. No significant changes of the blood volume have been observed. 14 days after treatment, the blood values were found to be practically within the normal range. As early as 3 days after the blood exchange, a significant increase in reticulocytes has been noted which reached its maximum on the 7th day. In both series the blood regeneration was identical.
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Nowadays, above all dextran, gelatin and starch solutions are available for the infusion theraphy of the various forms of shock. The application of these volume substitutes must be strictly controlled to avoid in particular cardial and pulmonal commplications. Blood transfusion combined with a volume substitute should only be applied in cases of heavy loss of blood. The treatment of metabolic acidose which usually occurs simultaneously is carried out with an alkaline solution.