Journal of feline medicine and surgery
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J. Feline Med. Surg. · Jun 2010
Controlled Clinical TrialEffects of multiple oral dosing of itraconazole on the pharmacokinetics of cyclosporine in cats.
Itraconazole (Icz) has been known to increase the cyclosporine (CsA) trough level in human transplant patients. However, the interaction of Icz with CsA has not been reported in cats. ⋯ Co-administration of Icz with CsA resulted in significant increases of oral bioavailability of CsA. The results of our study suggest that administration of multiple therapeutic doses of Icz may decrease the required CsA dosage in CsA-based immunosuppressive therapy used for renal transplantation in cats.