Advances in shock research
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Both exogenous glucose and adenosine triphosphate--magnesium chloride (ATP-MgCl2, used separately, have been reported to prolong survival after hemorrhagic shock. The purpose of this study was to determine whether intravenously administered glucose plus ATP-MgCl2 given together during hemorrhagic shock would improve cardiac function and survival. Further, we investigated whether glucose had any real additive effect when used in conjunction with ATP-MgCl2, by using ATP-MgCl2 alone and with equimolar mannitol. ⋯ Mean survival of those which received ATP-MgCl2-mannitol was statistically significantly greater at 200.8 +/- 10.3 minutes than ATP-MgCl2-glucose alone with Ringer's (p less than 0.01). Mean survival was greatest in those which received ATP-MgCl2 alone at 201.2 +/- 9.5 minutes (p less than 0.01), and statistically significantly greater than any other treatment group except ATP-MgCl2-mannitol. ATP-MgCl2 alone significantly increased survival compared to those which received ATP-MgCl2-glucose.