[Hokkaido igaku zasshi] The Hokkaido journal of medical science
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Hokkaido Igaku Zasshi · Jul 1993
Randomized Controlled Trial Clinical Trial[Behavioral control of breathing and the effect of endogenous opiates in chronic obstructive pulmonary disease].
Dyspnea is a common symptom in patients with chronic obstructive pulmonary disease (COPD) but its mechanism is unclear. It is known that the opiate antagonist, naloxone, restores in some patients with COPD the ability to compensate for a flow-resistive load (N Engl J Med 1981; 304; 1190-5). We studied the effect of naloxone on the threshold of resistive load detection (RLD) and on sensation of breathlessness in patient with COPD. ⋯ P: 0.89 +/- 0.44 during P vs 0.97 +/- 0.54 during NLX, NS. Gf/VE: 0.76 +/- 0.57 during P vs 1.38 +/- 0.62 during NLX, P < 0.01). FRC, VE, f, T1, TE and P0.1 did not significantly change after NLX.(ABSTRACT TRUNCATED AT 250 WORDS)