[Hokkaido igaku zasshi] The Hokkaido journal of medical science
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Hokkaido Igaku Zasshi · Sep 1993
[Effects of acidosis on the neuronal function following oxygen-glucose deprivation in the rat hippocampal slices].
This study was designed to examine 1) whether cerebral ischemic damage is aggravated by accompanying acidosis and 2) which has more potential to cause neural damage between respiratory and metabolic acidosis. To investigate these points, inhibition and recovery of hippocampal evoked potentials were studied in vitro with different pH solutions. Population spike (PS) activity was recorded from CA 1 region after stimulation of the Schaffer collaterals of the 400 microns hippocampal slices from young Wister rats. ⋯ By addition of CO2, the recovery of PS following OGD was inhibited to a similar degree as with 30 mM lactic acidosis. It is concluded that concomitant acidosis has divergent effects on the cerebral ischemic damage depending on the pH; mild acidosis had a protective effect but profound acidosis had an aggravating effect, the cross over point being at around pH 6.0. Lactate and CO2 potentiated the aggravating effects of acidosis even though the extracellular pH remained the same.