Swiss medical weekly
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Swiss medical weekly · Mar 1980
Case Reports[Progressive encephalopathy in 3 cases of chronic lymphoid leukemia].
Three patients suffering from a lymphoproliferative syndrome developed, late in the course of the disease, a neurological disorder with the signs and symptoms of a progressive multifocal leukoencephalopathy (PML). This diagnosis was confirmed in the first patient. ⋯ The involvement of the CNS in the evolution of lymphoproliferative disorders becomes more and more frequent, probably due to the prolonged survival time of patients undergoing chemotherapy and the immunosuppressive effects of such treatment. Biopsy is the only method of distinguishing PML from a cerebral leukemic infiltration; this is obviously important in view of the different therapeutic approaches used for the two diseases.
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Swiss medical weekly · Mar 1980
Case Reports[Loss of 2 kidney grafts due to recurrence of type II membrano-proliferative glomerulonephritis].
Recurrent glomerulonephritis after renal transplantation is seen in a very high percentage of patients with dense "deposit" disease (= membrano-proliferative glomerulonephritis type II). However, loss of graft due to recurrence is rare; only 4 cases have been reported. ⋯ Both had recurrent dense "deposit" disease with extracapillary proliferation and crescent formation. In one of them, a quiet initial phase of 20 months was followed by an extremely rapid progression of the disease leading to loss of graft function within 3 weeks.