Articles: respiratory-distress-syndrome.
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Critical care medicine · Feb 1995
Pentoxifylline prevents a decrease in arterial oxygen tension in oleic acid-induced lung injury.
a) To determine whether pentoxifylline has a preventive effect on the decrease in PaO2 that is caused by oleic acid, and whether pentoxifylline facilitates normalization of PaO2 from the decreased state. b) To examine whether pentoxifylline can attenuate an increase in pulmonary vascular permeability that is induced by oleic acid. ⋯ Pentoxifylline is a noteworthy drug that could be a candidate as a therapy to help prevent hypoxemia in lung injuries that share a common mechanism with oleic acid-induced lung injury.
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Critical care medicine · Feb 1995
Editorial CommentBarotrauma in acute lung injury: is it important?
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To analyze temporal trends in acute respiratory distress syndrome (ARDS) fatality rates since 1983 at one institution. ⋯ In this large series, we observed a significant decrease in fatality rates occurring largely in patients younger than 60 years and in those with sepsis syndrome as their risk for ARDS. We are unable to determine the extent to which experimental therapies or other changes in treatment have contributed to the observed decline in the ARDS fatality rate. Institution-specific rates and temporal trends in ARDS fatality rates should be considered in clinical trials designed to prevent ARDS and the high mortality associated with this syndrome.