Randomized Controlled Trial

L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease.

Atherosclerosis. 2009 May 1; 204 (1): 73-8.
Controlled Clinical Trial

(6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm.

Arterioscler. Thromb. Vasc. Biol. 2007 Jun 1; 27 (6): 1334-9.
Article

Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure.

J. Am. Soc. Nephrol. 2000 Feb 1; 11 (2): 301-9.