Meta Analysis

Side Effect Rates of Opioids in Equianalgesic Doses Via Intravenous Patient-Controlled Analgesia: A Systematic Review and Network Meta-analysis.

Anesth. Analg. 2019 Oct 1; 129 (4): 1153-1162.

Oxycodone, alfentanil and remifentanil PCAs result in significantly higher patient satisfaction than other opioids, although side-effect profiles are similar.
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Meta Analysis

Intraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysis.

Anesth. Analg. 2019 Dec 1; 129 (6): 172317321723-1732.

Clinical Trial

A Novel Perioperative Multidose Methadone-Based Multimodal Analgesic Strategy in Children Achieved Safe and Low Analgesic Blood Methadone Levels Enabling Opioid-Sparing Sustained Analgesia With Minimal Adverse Effects.

Anesth. Analg. 2021 Aug 1; 133 (2): 327337327-337.

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