• Peter Y Chen, Michelle Wallace, Christina Mitchell, Inga Grills, Larry Kestin, Ashley Fowler, Alvaro Martinez, and Frank Vicini.
• Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA.
• Int. J. Radiat. Oncol. Biol. Phys. 2010 Mar 15; 76 (4): 991-7.

PurposeThis prospective study examines the use of three-dimensional conformal external beam radiation therapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI). Four-year data on efficacy, cosmesis, and toxicity are presented.MethodsPatients with Stage O, I, or II breast cancer with lesions ResultsNinety-four patients are evaluable for efficacy. Median patient age was 62 years with the following characteristics: 68% tumor size <1 cm, 72% invasive ductal histology, 77% estrogen receptor (ER) (+), 88% postmenopausal; 88% no chemotherapy and 44% with no hormone therapy. Median follow-up was 4.2 years (range, 1.3-8.3). Four-year estimates of efficacy were IBF: 1.1% (one local recurrence); INF: 0%; CBF: 1.1%; DF: 3.9%; DFS: 95%; OS: 97%; and CSS: 99%. Four (4%) Grade 3 toxicities (one transient breast pain and three fibrosis) were observed. Cosmesis was rated good/excellent in 89% of patients at 4 years.ConclusionsFour-year efficacy, cosmesis, and toxicity using 3D-CRT to deliver APBI appear comparable to other experiences with similar follow-up. However, additional patients, further follow-up, and mature Phase III data are needed to evaluate thoroughly the extent of application, limitations, and complete value of this particular form of APBI.Copyright 2010 Elsevier Inc. All rights reserved.

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