• Jeremy J Cordingley, Dirk Vlasselaers, Natalie C Dormand, Pieter J Wouters, Stephen D Squire, Ludovic J Chassin, Malgorzata E Wilinska, Clifford J Morgan, Roman Hovorka, and Greet Van den Berghe.
• Adult Intensive Care Unit, Royal Brompton Hospital, Sydney Street, London, UK. j.cordingley@rbht.nhs.uk
• Intensive Care Med. 2009 Jan 1;35(1):123-8.

ObjectiveTo investigate the effectiveness of an enhanced software Model Predictive Control (eMPC) algorithm for intravenous insulin infusion, targeted at tight glucose control in critically ill patients, over 72 h, in two intensive care units with different management protocols.DesignComparison with standard care in a two center open randomized clinical trial.SettingTwo adult intensive care units in University Hospitals.Patients And ParticipantsThirty-four critically ill patients with hyperglycaemia (glucose >120 mg/dL) or already receiving insulin infusion.InterventionsPatients were randomized, within each ICU, to intravenous insulin infusion advised by eMPC algorithm or the ICU's standard insulin infusion administration regimen.Measurements And ResultsArterial glucose concentration was measured at study entry and when advised by eMPC or measured as part of standard care. Time-weighted average glucose concentrations in patients receiving eMPC advised insulin infusions were similar [104 mg/dL (5.8 mmol/L)] in both ICUs. eMPC advised glucose measurement interval was significantly different between ICUs (1.1 vs. 1.8 h, P < 0.01). The standard care insulin algorithms resulted in significantly different time-weighted average glucose concentrations between ICUs [128 vs. 99 mg/dL (7.1 vs. 5.5 mmol/L), P < 0.01].ConclusionsIn this feasibility study the eMPC algorithm provided similar, effective and safe tight glucose control over 72 h in critically ill patients in two different ICUs. Further development is required to reduce glucose sampling interval while maintaining a low risk of hypoglycaemia.

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