• Paul J Der Mesropian, John S Kalamaras, George Eisele, Kenneth R Phelps, Arif Asif, and Roy O Mathew.
• Clin Nephrol. 2014 Mar 1;81(3):174-84.

AimTo compare long-term outcomes in CA-AKI to HA-AKI. The hypothesis was that renal and patient survival would be better in CA-AKI than in HA-AKI.MethodsRetrospective cohort analysis of patients hospitalized from 2004 to 2005, in Upstate New York Veterans Affairs hospitals. The groups: CA-AKI (n = 560), HA-AKI (n = 158), or No AKI (NA) (n = 2,320). Risk, injury, failure, loss, and end-stage kidney (RIFLE) criterion was used to define AKI.Primary Outcomesdoubling of serum creatinine, endstage renal disease (ESRD), death, and a composite of the three.Secondary Outcomesde novo chronic kidney disease (CKD), recovery of renal function, and re-admission rate. The cumulative incidence of outcomes was determined over a period of 3 years after discharge.ResultsCA-AKI was 3.5 times as prevalent as HA-AKI. In comparison to patients with HA-AKI, those with CA-AKI had better estimated glomerular filtration rate (71.3 vs. 61.1 mL/min/1.73 m(2), p < 0.001) and lower prevalence of CKD (42.3 vs. 51.9%, p = 0.03) at baseline. More patients with CA-AKI than HA-AKI met RIFLE failure criterion (43.8 vs. 29.1%, p < 0.001). By 3 years, no differences were found for the individual primary and secondary outcomes tested (all p > 0.05).ConclusionsCA-AKI was found to be considerably more common than HA-AKI and had similar long-term consequences.

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