• J. Cardiothorac. Vasc. Anesth. · Oct 2017

    Randomized Controlled Trial Multicenter Study Comparative Study

    Effect of 0.9% Saline or Plasma-Lyte 148 as Crystalloid Fluid Therapy in the Intensive Care Unit on Blood Product Use and Postoperative Bleeding After Cardiac Surgery.

    • Sumeet K Reddy, Michael J Bailey, Richard W Beasley, Rinaldo Bellomo, Diane M Mackle, Alex J Psirides, and Paul J Young.
    • Medical Research Institute of New Zealand, Wellington, New Zealand. Electronic address: sumeetkreddy@gmail.com.
    • J. Cardiothorac. Vasc. Anesth. 2017 Oct 1; 31 (5): 1630-1638.

    ObjectiveTo evaluate the effect of Plasma-Lyte 148 (PL-148) compared with 0.9% saline (saline) on blood product use and postoperative bleeding in patients admitted to the intensive care unit (ICU) following cardiac surgery.DesignA post hoc subgroup analysis conducted within a multicenter, double-blind, cluster-randomized, double-crossover study (study 1) and a prospective, single-center nested-cohort study (study 2).SettingTertiary-care hospitals.ParticipantsAdults admitted to the ICU after cardiac surgery requiring crystalloid fluid therapy as part of the 0.9% saline vs. PL-148 for ICU fluid therapy (SPLIT) trial.InterventionsBlinded saline or PL-148 for 4 alternating 7-week blocks.Measurements And Main Results954 patients were included in study 1; 475 patients received PL-148, and 479 received saline. 128 of 475 patients (26.9%) in the PL-148 group received blood or a blood product compared with 94 of 479 patients (19.6%) in the saline group (OR [95% confidence interval], 1.51 [1.11-2.05]; p = 0.008). In study 2, 131 patients were allocated to PL-148 and 120 patients were allocated to saline. There were no differences between groups in chest drain output from the time of arrival in the ICU until 12 hours postoperatively (geometric mean, 566 mL for the PL-148 group v 547 mL in the saline group; p = 0.60).ConclusionsThe findings did not support the hypothesis that using PL-148 for fluid therapy in ICU following cardiac surgery reduces transfusion requirements compared to saline. The significantly increased proportion of patients receiving blood or blood product with allocation to PL-148 compared to saline was unexpected and requires verification through further research.Copyright © 2017 Elsevier Inc. All rights reserved.

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