The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
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J. Matern. Fetal. Neonatal. Med. · Jun 2018
Perinatal SSRI exposure permanently alters cerebral serotonin receptor mRNA in mice but does not impact adult behaviors.
Associations have been made between maternal selective serotonin reuptake inhibitor (SSRI) use during pregnancy and altered behavior in offspring, including an increased risk of autism. Given the important role serotonin plays in behavior, we hypothesized SSRI exposure in the perinatal period would alter central serotonin receptor expression and program adult behaviors in mice. ⋯ Although no behavioral phenotype was observed, SSRI exposure in the perinatal period permanently alters cerebral receptor mRNA levels. We speculate these shifts in mRNA expression provide important compensation during SSRI exposure. Further pre-clinical and clinical investigation into additional serotonin-regulated phenotypes is necessary to further assess the long-term implications of perinatal SSRI exposure.
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J. Matern. Fetal. Neonatal. Med. · May 2018
Multicenter StudyAnesthesia management of complete versus incomplete placenta previa: a retrospective cohort study.
Placenta previa (PP) is a major cause of obstetric hemorrhage. Clinical diagnosis of complete versus incomplete PP has a significant impact on the peripartum outcome. Our study objective is to examine whether distinction between PP classifications effect anesthetic management. ⋯ Complete PP is associated with increased risk of hemorrhage compared with incomplete PP. Therefore distinction between classifications should be factored into anesthetic management protocols.
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J. Matern. Fetal. Neonatal. Med. · May 2018
The relationship between the five minute Apgar score, mode of birth and neonatal outcomes.
To investigate the relationship between the five-minute Apgar score categories (low, intermediate, and normal), mode of birth and neonatal outcomes. ⋯ Low and intermediate five minute Apgar scores were strongly associated with mode of birth and poorer neonatal outcomes.
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J. Matern. Fetal. Neonatal. Med. · Apr 2018
Association between prior vaginal birth after cesarean and subsequent labor outcome.
To estimate the effect of prior successful vaginal birth after cesarean (VBAC) on the rate of uterine rupture and delivery outcome in women undergoing labor after cesarean. ⋯ In women attempting labor after cesarean, prior VBAC appears to be associated with lower rate of uterine rupture and higher rate of successful vaginal birth.
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J. Matern. Fetal. Neonatal. Med. · Mar 2018
Observational StudyInfluence of difficulty of instrumentation with vacuum on the rate of levator ani muscle avulsion identified by 3-4 d transperineal ultrasound.
Evaluation of the influence of difficulty of instrumentation with vacuum on the rate of levator ani muscle (LAM) avulsions. ⋯ The number of vacuum tractions needed to complete fetal extraction is not associated to a higher LAM avulsion rate nor with differences in levator hiatus area.