The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
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J. Matern. Fetal. Neonatal. Med. · Jan 2016
Observational StudyFoetal heart rate deceleration with combined spinal-epidural analgesia during labour: a maternal haemodynamic cardiac study.
To understand the mechanisms those are involved in the appearance of foetal heart rate decelerations (FHR) after the combined epidural analgesia in labour. Observational study done at University Hospital for 86-term singleton pregnant women with spontaneous labour. Serial bedside measurement of the main cardiac maternal parameters with USCOM technique; stroke volume (SV), heart rate (HR), cardiac output (CO) and total vascular resistances (TVR) inputting systolic and diastolic blood pressure before combined epidural analgesia and after 5', 10', 15' and 20 min. ⋯ The level of TVR before combined epidural analgesia in labour may indicate the risk of FHR abnormalities after the procedure. Low TVR (<1000 dyne/s/cm(-5)) showed a reduced risk of FHR abnormalities. FHR decelerations seem to occur in women without the ability to upregulate SV and CO in response to the initial effects of analgesia.
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J. Matern. Fetal. Neonatal. Med. · Jan 2016
Controlled Clinical TrialPolicy of high-dose tranexamic acid for treating postpartum hemorrhage after vaginal delivery.
To assess whether a policy of routine administration of high-dose tranexamic acid (TA) at the diagnosis of postpartum hemorrhage (PPH) reduces blood loss after vaginal birth. ⋯ A policy of high-dose TA in PPH after vaginal deliveries was not associated with a significant reduction of blood loss.
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J. Matern. Fetal. Neonatal. Med. · Jan 2016
Review Meta AnalysisCarbetocin for the prevention of postpartum hemorrhage: a systematic review and meta-analysis of randomized controlled trials.
To compare the efficacy and safety profile of carbetocin with other uterotonic agents in preventing postpartum hemorrhage. ⋯ Carbetocin has been associated with a similar low incidence of adverse effects to oxytocin and at least as effective as syntometrine and may become an alternative uterotonic agent for the prevention of postpartum hemorrhage. Further studies should be conducted to determine the safety and efficacy profile of carbetocin in women with cardiac disorders and to analyze the cost-effectiveness and minimum effective dose of carbetocin.
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J. Matern. Fetal. Neonatal. Med. · Jan 2016
Serum VEGF and PGF may be significant markers in prediction of severity of preeclampsia.
The aim of this study evaluate the value of vascular endothelial growth factor (VEGF) and placental growth factor (PGF) serum levels in prediction of preeclampsia, severity and onset time of the disease. ⋯ VEGF and PGF may be significant markers in prediction of severity of preeclampsia, and VEGF may also be valuable in prediction of preeclampsia.
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J. Matern. Fetal. Neonatal. Med. · Jan 2016
Clinical TrialRole of presepsin in the diagnosis of late-onset neonatal sepsis in preterm infants.
One of the most challenging aspects in the management of neonates with late-onset neonatal sepsis (LOS) is to make the diagnosis. Presepsin is a novel and promising marker of sepsis. The aim of this study was to assess the role of presepsin in the diagnosis of LOS in preterm infants. ⋯ Presepsin can be used as a reliable biomarker for LOS and treatment response in preterm infants. However, we could not demonstrate the efficacy of presepsin for the detection of disease severity or prognosis.