The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
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J. Matern. Fetal. Neonatal. Med. · Nov 2011
Randomized Controlled Trial Multicenter StudyEfficacy and safety of oral iron(III) polymaltose complex versus ferrous sulfate in pregnant women with iron-deficiency anemia: a multicenter, randomized, controlled study.
To evaluate the efficacy and safety of iron(III) polymaltose complex (Maltofer(®)) versus ferrous sulfate in iron-deficient pregnant women using recommended doses. ⋯ Oral iron(III) polymaltose complex offers at least equivalent efficacy and a superior safety profile compared to ferrous sulfate for the treatment of iron-deficiency anemia during pregnancy.
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J. Matern. Fetal. Neonatal. Med. · Nov 2011
Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia.
To evaluate the association between endothelial activation markers in the maternal circulation with nitric oxide (NO) synthesis in human umbilical endothelial cells. ⋯ High circulating levels of maternal endothelial dysfunction markers present in pre-eclampsia are associated with decreased NO synthesis in fetal endothelium.
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J. Matern. Fetal. Neonatal. Med. · Nov 2011
Glucocorticoid receptor expression and cortisol level in cord blood of term infants.
To examine the expression levels of glucocorticoid receptor (GR) isoforms in peripheral blood mononuclear cells (PBMCs) and serum cortisol levels in cord blood from term infants. ⋯ It is considered that glucocorticoid effects could be expected from the fetal period to the neonatal period, because GRalpha expression level was not related to perinatal factors, GRbeta expression level, and cortisol level in term infants. Further studies of larger populations including very preterm and small for gestational age infants are necessary to determine the balance of expression between GRalpha and GRbeta, and cortisol level.
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J. Matern. Fetal. Neonatal. Med. · Nov 2011
Case ReportsA noninvasive evaluation analysis of amniotic fluid embolism and disseminated intravascular coagulopathy.
Amniotic fluid embolism (AFE) is a complication of pregnancy with a high mortality rate. The diagnosis of AFE is currently based on clinical findings, acute respiratory distress, cardiovascular collapse during labor and delivery, and immediate massive postpartum hemorrhaging. The serum biological markers are unreliable, and their detection requires a long time intervals for result. An early diagnosis is very important and prompts the clinical management of the condition. ⋯ We show that these methods can be successfully applied to the diagnosis of AFE and predict the prognosis of DIC. We also show that CT scans can be applied to the diagnosis of pulmonary embolism, eliminating the need to pathology.
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Shock is a clinical disorder that challenges caregivers in the neonatal intensive care unit. The predominant cause of shock in neonates is sepsis. This article provides an overview of the current treatment of septic shock with particular emphasis on newer vasoactive drugs (milrinone, levosimendan and vasopressin) to support cardiovascular dysfunction.