The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
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J. Matern. Fetal. Neonatal. Med. · Feb 2009
Case ReportsMaternal thrombocytopenia-absent radius syndrome complicated by severe pre-eclampsia.
Thrombocytopenia-absent radius (TAR) syndrome affects 0.5-1/100,000 live births. We describe, to the best of our knowledge, the sixth patient with TAR to experience a successful pregnancy and the first such case complicated by severe pre-eclampsia. ⋯ Repeat cesarean delivery was performed at 33 4/7 weeks' gestation. Obstetrical conditions characterised by thrombocytopenia may present diagnostic challenges and should be considered in the differential diagnosis of thrombocytopenic exacerbations in TAR syndrome.
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J. Matern. Fetal. Neonatal. Med. · Jan 2009
Randomized Controlled TrialEfficacy of tranexamic acid in reducing blood loss after cesarean section.
To assess the efficacy and safety of tranexamic acid in reducing blood loss at caesarian section (CS). ⋯ Tranexamic acid statistically reduces blood loss from end to 2 h after CS and its use was not associated with any side effects or complications. Consequently, tranexamic acid can be used safely and effectively to reduce bleeding resulting from CS.
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J. Matern. Fetal. Neonatal. Med. · Jan 2009
Breastfeeding the 'healthy' near-term infants after laryngeal mask airway or traditional resuscitation methods.
The influence of delivery room resuscitation practice on neonatal breastfeeding pattern is largely not data driven, and clinical experience is insufficient to indicate the impact of available management methods. ⋯ LMA is an effective and safe alternative to more conventional forms of airway management in near-term infants needing resuscitation at birth. Other studies are needed to clarify the potential advantages of the LMA on breastfeeding.
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J. Matern. Fetal. Neonatal. Med. · Jan 2009
The impact of ibuprofen or indomethacin on renal drug clearance in neonates.
Administration of ibuprofen or indomethacin in neonates is associated with a reduction of glomerular filtration, reflected in a reduction in the elimination of drugs dependent on renal function for clearance. However, the magnitude of these effects and potential differences between ibuprofen or indomethacin remain unclear. ⋯ Both ibuprofen and indomethacin have a quantifiable impact on renal drug clearance. Compared to ibuprofen, the impact of indomethacin is more pronounced. Population modelling with covariate analysis can be a tool to disentangle the impact of various covariates, including ibuprofen or indomethacin, on renal drug clearance.
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J. Matern. Fetal. Neonatal. Med. · Jan 2009
Randomized Controlled Trial Multicenter StudySide effects of oral misoprostol for the prevention of postpartum hemorrhage: results of a community-based randomised controlled trial in rural India.
To investigate the side effects of 600 microg oral misoprostol given for the mother and the newborn to prevent postpartum hemorrhage (PPH). ⋯ Misoprostol is associated with a significant increase in postpartum maternal shivering and fever with no side effects for the newborn. Given its proven efficacy for the prevention of PPH, the benefits of misoprostol are greater than the associated risks.