Lancet neurology
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Biography Historical Article
Alim-Louis Benabid: stimulation and serendipity.
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Randomized Controlled Trial Multicenter Study
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.
In an open-label phase 1 trial, gene delivery of the trophic factor neurturin via an adeno-associated type-2 vector (AAV2) was well tolerated and seemed to improve motor function in patients with advanced Parkinson's disease. We aimed to assess the safety and efficacy of AAV2-neurturin in a double-blind, phase 2 randomised trial. ⋯ Ceregene and Michael J Fox Foundation for Parkinson's Research.