Lancet neurology
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Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare cause of demyelinating neuropathy, with multi-organ involvement characterised by plasma cell dyscrasia and VEGF overproduction. No treatments have been established for patients with POEMS syndrome who are not eligible for stem-cell transplantation. Thalidomide suppresses VEGF and plasma cell proliferation. We aimed to assess the safety and efficacy of thalidomide for the treatment of POEMS syndrome. ⋯ Japanese Ministry of Health, Labour, and Welfare, and Fujimoto Pharmaceuticals.
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Biography Historical Article
Claudia Lucchinetti: clinician, scientist, and leader.