Lancet neurology
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Multicenter Study
Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model.
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive, fatal motor neuron disease with a variable natural history. There are no accurate models that predict the disease course and outcomes, which complicates risk assessment and counselling for individual patients, stratification of patients for trials, and timing of interventions. We therefore aimed to develop and validate a model for predicting a composite survival endpoint for individual patients with ALS. ⋯ Netherlands ALS Foundation.
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Biography Historical Article
Frederik Barkhof: building bridges between disciplines.