Lancet neurology
The most recent articles from:
Lancet Neurol
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Markers of neuroinflammation are increased in some patients with LRRK2 Parkinson's disease compared with individuals with idiopathic Parkinson's disease, suggesting possible differences in disease pathogenesis. Previous PET studies have suggested amplified dopamine turnover and preserved serotonergic innervation in LRRK2 mutation carriers. We postulated that patients with LRRK2 mutations might show abnormalities of central cholinergic activity, even before the diagnosis of Parkinson's disease. ⋯ Michael J Fox Foundation, National Institutes of Health, and Pacific Alzheimer Research Foundation.
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Letter Historical Article
MPTP-induced parkinsonism: an historical case series.