Ugeskrift for laeger
-
Ugeskrift for laeger · Mar 2009
[Brain injury marker S100B can reduce the use of computer tomography in minor head injuries--secondary publication].
The risk of acute intracranial complications after minor head injury (MHI) is low. Despite this, computed tomography (CT) is generally recommended with clinical observation as a secondary option. ⋯ The specificity of S100B is low, but a high sensitivity for brain damage results in a clinically useful, high negative predictive value (NPV). Integration of S100B into existing management routines can reduce the need for CT scans or admission by over 30%.
-
Ugeskrift for laeger · Mar 2009
[Evidence-based pharmacological interventions in intensive therapy].
Very few randomised controlled trials (RCTs) conducted in intensive care units and using mortality as their primary outcome have shown a beneficial effect of pharmacological intervention on survival. Other types of evidence than the RCT should therefore be considered. Observational studies (clinical epidemiological studies) based on public registers and clinical databases have shown good agreement with the results from RCTs. The populations of Denmark and the remaining Scandinavian countries are well-registered and as such an ideal base for clinical, epidemiological studies supplementing the RCTs.