Ugeskrift for laeger
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The new version of the GOLD document on chronic obstructive pulmonary disease (COPD), introduces a profound change in the stratification of the patients. In addition to the level of forced expiratory volume in the first second (FEV1), the new stratification also includes the level of daily symptoms, in particular dyspnoea, and the history of exacerbations. This review describes this stratification and the treatment of stable COPD according to the GOLD document. It focuses on early diagnosis, smoking cessation, rehabilitation and medical treatment.
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Genetic haemochromatosis is a complex disorder/disease, which can be caused by a multiplicity of mutations in genes involved in iron metabolism being located on different chromosomes. In Caucasians, mutations in the HFE-gene account for the most common form of haemochromatosis (type 1). Non-HFE-haemochromatoses are less frequent and consist of juvenile haemochromatosis (type 2A and 2B) and TRF2-related haemochromatosis (type 3), which all respond to phlebotomies. The others comprise ferroportin disease (type 4A) atypical ferroportin disease (type 4B), acoeruloplasminaemia, atransferrinaemia and DMT1-associated haemochromatosis.
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Ugeskrift for laeger · Apr 2013
Case Reports[Orf parapoxvirus can infect humans after relevant exposure].
Orf virus occurs worldwide among sheep and goats. Transmission to humans is seen by close contact with infected animals, but the incidence in Denmark is unknown. ⋯ Upon conservative treatment the infected areas healed without sequelae. We shortly discuss the epidemiology, the natural history, the treatment and the complications of orf virus.