Ugeskrift for laeger
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Malignant hyperthermia susceptibility is a rare pharmacogenetic muscular disorder that may lead to potentially fatal complications in routine anesthesia. Malignant hyperthermia is triggered by volatile anesthetics and succinylcholine. ⋯ Although progress is made in our knowledge of the genetics behind malignant hyperthermia, muscle biopsy and in-vitro contracture testing is still the only way to diagnose malignant hyperthermia susceptibility in the vast majority of cases. Danish Malignant Hyperthermia Center at the Anesthetic Department of Herlev University Hospital, DK-2730 Herlev, takes care of all testing for malignant hyperthermia in Denmark and keeps a registry of all Danes with known or suspected susceptibility to malignant hyperthermia.
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Ugeskrift for laeger · Apr 2003
[Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents].
Continuous intrathecal baclofen has been used over the past years especially in adult patients with spasticity of spinal origin. Children and young adults with severe spasticity and dystonia of cerebral origin are difficult to treat in spite of optimal systemic antispasmotic therapy with baclofen, tizanidine, dantrolene and/or diazepam. Intrathecal baclofen has therefore been applied in a group of young patients. ⋯ Continuous intrathecal baclofen was effective in treating severe spasticity and dystonia of cerebral origin with major effect on muscles of the lower extremities, pelvis, and back and in particular opisthotonus was relieved. Efficacy on upper extremities was far less pronounced.
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Ugeskrift for laeger · Apr 2003
Randomized Controlled Trial Comparative Study Clinical Trial[Remifentanil and eye surgery. A randomized, clinical comparison of propofol/remifentanil anesthesia and propofol/fentanyl/alfentanil anesthesia].
The aim of this study was to investigate how many patients, after anesthesia with either propofol/remifentanil or propofol/fentanyl/alfentanil, within 20 minutes from the end of surgery could be transferred directly to the general ward. The number of undesired preoperative incidents, the anesthetists', the surgeons', and the patients' evaluations of the anesthesia were registered. An evaluation of the economic consequences of the two methods was also intended. ⋯ With a propofol/remifentanil-anesthesia, the patients had a predictably short awakening time, so they could be transferred directly to the general ward. This may, especially in ambulatory surgery, mean cost savings and perhaps higher patient satisfaction.