Ugeskrift for laeger
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Ugeskrift for laeger · Jan 2001
Review[Mortality after administration of human albumin to critically ill patients with hypovolemia. An analysis of a systematic Cochrane review].
A systematic Cochrane review strongly suggested that the administration of human albumin to critically ill patients with hypovolaemia increases mortality. This review has been widely criticised and the aim of the present paper was to analyse the original studies with regard to 1) the randomisation procedure, 2) the blinding procedure, 3) the indication of treatment, 4) whether treatment was clearly defined and consistent, 5) how normovolaemia was defined, and 6) the length of the follow-up period. ⋯ Consequently, there is no scientific evidence to support the conclusion that human albumin administered to critically ill patients with hypovolaemia increases the mortality. Thus, the validity and quality control of systematic Cochrane reviews may be questioned.
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Ugeskrift for laeger · Jan 2001
Review[Accelerated surgical stay programs. A professional and administrative challenge].
Accelerated surgical stay programs represent a multi-modal, multi-disciplinary concept to reduce postoperative morbidity, hospitalisation and convalescence based upon recent advantages in surgical pathophysiology and pain treatment. Preliminary data from a variety of surgical procedures suggest major improvements in quality of surgical care and cost reduction and call for further controlled or large-size multi-center studies.
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Ugeskrift for laeger · Jan 2001
Review[Gabapentin--yet another antiepileptic agent for the treatment of neuropathic pain?].
Gabapentin is a recently introduced anti-epileptic drug used as an adjuvant in partial and secondarily generalised tonic-clonic seizures. Its mechanism of action has not been fully elucidated, but it seems that gabapentin may regulate voltage-dependent calcium channels, presumably on a spinal level, in the nociceptive system. ⋯ The adverse effects associated with gabapentin treatment are relatively harmless, mild to moderate in severity, and usually transient, with tolerance developing 2-3 weeks after start of treatment. Gabapentin and tricyclic antidepressants are efficacious in the treatment of painful diabetic neuropathy and postherpetic neuralgia.
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Ugeskrift for laeger · Jan 2001
Case Reports[An unusual complex of debut symptoms in Wegener's granulomatosis].
We report an unusual case of Wegener's granulomatosis in a patient presenting with stridor and tracheal narrowing as the initial manifestation of the disease.