Asian Pacific journal of cancer prevention : APJCP
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Asian Pac. J. Cancer Prev. · Jan 2012
Mechanisms of anticancer activity of sulforaphane from Brassica oleracea in HEp-2 human epithelial carcinoma cell line.
Sulforaphane (SFN) an isothiocyanate formed by hydrolysis of glucosinolates found in Brassica oleraceae is reported to possess anticancer and antioxidant activities. In this study, we isolated SFN from red cabbage (Brassica oleraceae var rubra) and evaluated the comparative antiproliferative activity of various fractions (standard SFN, extract and purified SFN) by MTT assay in human epithelial carcinoma HEp -2 and and Vero cells. Probable apoptotic mechanisms mediated through p53, bax and bcl-2 were also examined. ⋯ Results showed that Std SFN and purified SFN concentration found to have closer IC50 which is equal to 58.96 microgram/ml (HEp-2 cells), 61.2 microgram/ml (Vero cells) and less than the extract which is found to be 113 microgram/ml (HEp-2 cells) and 125 microgram/ml (Vero cells). Further studies on apoptotic mechanisms showed that purified SFN down-regulated the expression of bcl-2 (antiapoptotic), while up-regulating p53 and Bax (proapoptotic) proteins, as well as caspase-3. This study indicates that purified SFN possesses antiproliferative effects the same as Std SFN and its apoptotic mechanism in HEp-2 cells could be mediated through p53 induction, bax and bcl-2 signaling pathways.
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Asian Pac. J. Cancer Prev. · Jan 2011
Treatment of cervical carcinoma with high-dose rate intracavitary brachytherapy: two years follow-up study.
This study focused on pelvic recurrence rate and late complications following treatment with high dose rate brachytherapy with a three fractionation scheme. ⋯ Using a three fraction scheme, high dose rate brachytherapy is safe and effective in the management of cervix cancer.
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Asian Pac. J. Cancer Prev. · Jan 2011
Knowledge of health effects and intentions to quit among smokeless tobacco users in India: findings from the International Tobacco Control Policy Evaluation (ITC) India Pilot Survey.
The prevalence of smokeless tobacco use in India is the highest in the world, with 26% of adults reporting being users of smokeless tobacco only. But to date, there are few studies of beliefs, knowledge, and other psychosocial measures relating to smokeless tobacco use in India. The aim of the present study was to use data from the ITC India Pilot Study conducted in 2006 to examine beliefs about the harms of smokeless tobacco use, knowledge of health effects, and intentions to quit among current smokeless tobacco users in two states, Maharashtra and Bihar. ⋯ Despite the fairly high levels of awareness of health effects from smokeless tobacco use in Maharashtra and Bihar, the majority of smokeless users had no intentions to quit. Increased educational efforts about the detrimental health effects from smokeless tobacco use may result in higher levels of knowledge about the harms of smokeless tobacco and this in turn could increase quit intentions and subsequent quitting among users.
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Asian Pac. J. Cancer Prev. · Jan 2011
Current status of thyroid cancer screening in Korea: results from a nationwide interview survey.
Since 2000, thyroid cancer has been increasing most rapidly in Korea. Although the cause of the increase is not clear, thyroid cancer screening could be identified as one of its causes. The purpose of this study was to examine the screening rate of thyroid cancer and its related factors using nationwide data. ⋯ We presented the number and characteristics of examinees utilized ultrasonography as a thyroid screening tool in Korea. Although these results revealed that cancer screening might play a major role in the increase of thyroid cancer incidence, further research is needed to determine causes of the rapidly increasing incidence of thyroid cancer in Korea.
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Asian Pac. J. Cancer Prev. · Jan 2011
Multivariate analysis of prognostic factors in gastric cancer patients using additive hazards regression models.
Gastric cancer is the second leading cause of cancer death worldwide and is the most common type of cancer in Iran. The objective of this research was to apply additive hazards models to the study of survival of patients with gastric cancer and to compare with results obtained using the Cox model. ⋯ Since Cox and Aalen models give different aspects of the association between risk factors and the study outcome, it seems desirable to use then together to give a more comprehensive understanding of data. Our results also suggest that early detection of patients at younger age and in primary stages is important to increase survival of patients with gastric cancer.