IEEE transactions on bio-medical engineering
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We have studied muscle recruitment with Teflon-insulated, 25 microns diameter, Pt-Ir intrafasicular electrodes implanted in nerves innervating the gastrocnemius and soleus muscles of cats. The purpose of this study was to measure the performance of these bipolar electrodes, which had been designed to optimize their ability to record unit activity from peripheral nerves, as stimulating electrodes. Recruitment curves identified the optimal stimulus configuration as a biphasic rectangular pulse, with an interphase separation of about 500 microseconds and a duration of about 50 microseconds. ⋯ Current and charge densities needed for stimulation were well below levels believed to be safe for the tissue and electrode materials involved. When the spinal reflex pathway was interrupted by crushing the nerve, the force produced by a given stimulus changed in some cases, but not in others, implying that the spinal reflex contribution was not the same in all the implants. We conclude that intrafascicular recording electrodes are also a potentially valuable technology for functional neuromuscular stimulation, and warrant further development.
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IEEE Trans Biomed Eng · Jun 1991
A simple analytical solution to the three-compartment pharmacokinetic model suitable for computer-controlled infusion pumps.
The disposition of many drugs following an intravenous bolus injection can be described by a biexponential or triexponential equation. Computer-controlled infusion pumps have been developed which dose intravenous drugs based on models of drug disposition. These pumps can maintain steady plasma drug concentrations and facilitate controlled increases and decreases in drug concentration, enhancing titration of intravenous drugs. ⋯ Because of the complexity of these analytical solutions, other investigators have used numerical techniques to approximate the analytical solution. We have derived an extremely simple analytical solution to polyexponential disposition functions. This solution simplifies both the prediction of the plasma drug concentration by a computer-controlled infusion pump and the stepwise calculation of the infusion rate required to maintain constant plasma drug concentrations.
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IEEE Trans Biomed Eng · Apr 1991
Nonlinear interpolation of mandibular kinesiographic signals by applying sensitivity method to a GMDH correction model.
The purpose of the present paper was to propose an improved nonlinear interpolation method for estimating distorted kinesiographic recording of interlattice points in space, and to evaluate its correction accuracy. The group method of data handling (GMDH) correction method we have reported previously is essentially different from other geometric correction methods in the sense that the GMDH correction model can be adapted to the measurement environment in which kinesiographic signals are subject to ferromagnetic interferences. Due to its inherent structure, however, our previous GMDH correction model was restricted to kinesiographic signals representing lattice points in space. ⋯ Distorted signals were corrected by the new method of correction modeling. A mean estimation error of 0.16 mm (SD 0.19 mm) was determined for 24 interlattice coordinates. Thus, nonlinear interpolation by the sensitivity method was confirmed to be effective.
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IEEE Trans Biomed Eng · Jan 1991
Epidural spinal cord stimulation: calculation of field potentials with special reference to dorsal column nerve fibers.
The effect of electrical stimulation with several electrode combinations on nerve fibers with different orientations in the spinal cord was investigated by computing the steady-state field potentials and activating functions. At first an infinite homogeneous model was used while secondly the spinal cord and its surrounding tissues were modeled as an inhomogeneous anisotropic volume conductor. ⋯ With anodal stimulation the opposite will occur. It was found that parameters substantially affecting the potential distribution in the dorsal columns are the conductivity of the white matter and the width and the conductivity of the csf layer.
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Closed-circuit anesthesia (CCA) is more economical and ecologically safer than open circuit anesthesia. However, gas concentrations are more difficult to control. Computer control of CCA has been proposed to facilitate its use. ⋯ The adaptive controller performed better than the fixed controller in all cases. The most significant difference was in the anesthetic gas response time 3.6 +/- 0.70 min for adaptive control and 7.04 +/- 5.62 min for fixed control. The adaptive controller was also robust with respect to variations in the system parameters such as the functional residual capacity, leak, deadspace and gas uptakes.(ABSTRACT TRUNCATED AT 250 WORDS)