IEEE transactions on bio-medical engineering
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IEEE Trans Biomed Eng · Aug 2016
A Novel Analysis Technique for Transcutaneous Measurement of Glomerular Filtration Rate With Ultralow Dose Marker Concentrations.
A novel high-precision approach [lifetime-decomposition measurement (LTDM)] for the assessment of the glomerular filtration rate (GFR) based on clearance measurements of exogenous filtration marker. ⋯ LTDM aims to resolve the issue of the currently necessary large doses of fluorescence tracer required for transcutaneous GFR measurement. Due to substantially less influences from autofluorescence and artifacts, the proposed method outperforms other existing techniques for accurate percutaneous organ function measurement.
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IEEE Trans Biomed Eng · Aug 2016
Less Invasive and Inotrope-Reduction Approach to Automated Closed-Loop Control of Hemodynamics in Decompensated Heart Failure.
We have been developing an automated cardiovascular drug infusion system for simultaneous control of arterial pressure (AP), cardiac output (CO), and left atrial pressure (PLA) in decompensated heart failure (HF). In our prototype system, CO and PLA were measured invasively through thoracotomy. Furthermore, the control logic inevitably required use of inotropes to improve hemodynamics, which was not in line with clinical HF guidelines. ⋯ Pulmonary artery catheterization confirmed optimization of hemodynamics (AP, from 98 ± 4 to 74 ± 11 mmHg; CO, from 2.2 ± 0.5 to 2.9 ± 0.3 L·min(-1)·m(-2); PCWP, from 27.0 ± 6.6 to 13.8 ± 3.0 mmHg). In a minimally invasive setting while reducing the use of inotrope, our system succeeded in automatically optimizing the overall hemodynamics in canine models of HF. The present results pave the way for clinical application of our automated drug infusion system.
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IEEE Trans Biomed Eng · Jul 2016
Scalable High-Performance Image Registration Framework by Unsupervised Deep Feature Representations Learning.
Feature selection is a critical step in deformable image registration. In particular, selecting the most discriminative features that accurately and concisely describe complex morphological patterns in image patches improves correspondence detection, which in turn improves image registration accuracy. Furthermore, since more and more imaging modalities are being invented to better identify morphological changes in medical imaging data, the development of deformable image registration method that scales well to new image modalities or new image applications with little to no human intervention would have a significant impact on the medical image analysis community. ⋯ Using the LONI and ADNI imaging datasets, image registration performance was compared to two existing state-of-the-art deformable image registration methods that use handcrafted features. To demonstrate the scalability of the proposed image registration framework, image registration experiments were conducted on 7.0-T brain MR images. In all experiments, the results showed that the new image registration framework consistently demonstrated more accurate registration results when compared to state of the art.
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The purpose of this paper is to regulate the blood glucose level in Type 1 Diabetes Mellitus patients with a practical and flexible procedure that can switch among a finite number of distinct controllers, depending on the user's choice. ⋯ This flexible procedure opens the possibility of taking into account, at the design stage, unannounced meals and/or patients' physical exercise.
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IEEE Trans Biomed Eng · Jun 2016
Noncontact Monitoring of Blood Oxygen Saturation Using Camera and Dual-Wavelength Imaging System.
We present a noncontact method to monitor blood oxygen saturation (SpO2). The method uses a CMOS camera with a trigger control to allow recording of photoplethysmography (PPG) signals alternatively at two particular wavelengths, and determines the SpO2 from the measured ratios of the pulsatile to the nonpulsatile components of the PPG signals at these wavelengths. The signal-to-noise ratio (SNR) of the SpO2 value depends on the choice of the wavelengths. ⋯ We also conducted a small pilot study to validate the noncontact method over an SpO2 range of 83%-98%. This study results are consistent with those measured using a reference contact SpO2 device ( r = 0.936, ). The presented method is particularly suitable for tracking one's health and wellness at home under free-living conditions, and for those who cannot use traditional contact-based PPG devices.