Journal of women's health
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Journal of women's health · Oct 2024
Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke.
Introduction: Females suffer greater lifetime risk of stroke and greater morbidity and mortality from stroke compared with males. This study's objective was to identify differences in metabolomic profiling of females and males with stroke and which differences were associated with neurological outcome. Methods: Females and males with acute ischemic stroke enrolled in the Emergency Medicine Specimen Bank at a comprehensive stroke center provided whole blood samples upon arrival for mass spectrometry-based metabolomics. ⋯ GDP and dehydroascorbate were significantly associated with 24-hour NIHSS (p = 0.0991). Conclusions: Few metabolites were differentially abundant in blood after a stroke when comparing females with males and controlling for confounders, but the interactions between biological sex and GDP, as well as biological sex and dehydroascorbate, were associated with 24-hour neurological function. This has important implications for future studies that evaluate the therapeutic potential of these metabolites in ischemic stroke.
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Journal of women's health · Oct 2024
Strengthening Maternal and Infant Health Resilience Before Weather and Climate Disasters: Preparedness Resources from CDC's Division of Reproductive Health.
This report describes opportunities to address emergency preparedness to incorporate the needs of pregnant and postpartum populations. This report briefly summarizes data on the impacts of weather and climate disasters on maternal and infant health and outlines opportunities for individuals, health care providers, and public health practitioners to increase capacity to prepare for these occurrences, which are becoming more frequent and costly. ⋯ S. Centers for Disease Control and Prevention's Division of Reproductive Health are shared to support individual preparedness, communication of disaster safety messages, and emergency preparedness planning capacity among health care providers and health departments.
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Journal of women's health · Oct 2024
Sex Differences Across the Lifespan: A Focus on Cardiometabolism.
Women's health and sex differences research remain understudied. In 2022, to address the topic of sex differences, the Ludeman Family Center for Women's Health Research (LFCWHR) at the University of Colorado (LudemanCenter.org) held its third National Conference, "Sex Differences Across the Lifespan: A Focus on Metabolism." The research presentations and discussions from the 2022 conference addressed cardiometabolic sex differences across the lifespan and included sessions focusing on scientific methods with which to study sex differences, effects of estrogen on metabolism, and sex differences in cardiovascular disease-implications for women and policy among others. ⋯ The meeting proceedings reveal that although exciting advances in the area of sex differences have taken place, significant questions and gaps remain about women's health and sex differences in critical areas of health. Identifying these gaps and the subsequent research that will result may lead to important breakthroughs.
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Journal of women's health · Oct 2024
Pregnancy Intendedness Among Racial and Ethnically Minoritized Women with Disabilities.
Background: A limited number of studies have examined the prevalence of unintended pregnancy among disabled women. However, no studies to date have examined the association between pregnancy intention and disability, in combination with race and ethnicity. Methods: We analyzed data from the National Survey of Family Growth from the period 2011-2019 to estimate the prevalence of pregnancy intendedness among women with disabilities 15-45 years of age. ⋯ After adjusting for demographic characteristics, results were slightly attenuated in all categories, with the exception of nondisabled Hispanic women, indicating high prevalence of unintended pregnancies. Conclusions: Racial and ethnic minority women with disabilities may experience heightened risk for unintended pregnancy. Targeted efforts are needed to address barriers to comprehensive sexual and reproductive health care and improve reproductive health outcomes among women who experience multiple forms of marginalization.