Journal of women's health
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Journal of women's health · Mar 2009
Review Meta AnalysisOvarian preservation by GnRH agonists during chemotherapy: a meta-analysis.
Treatment with cyclophosphamide (CYC) confers up to a 40% risk of ovarian failure in women of reproductive age. The use of GnRH agonists (GnRHa) to preserve ovarian function has been investigated in several small studies. We performed a systematic review of studies examining whether a GnRHa administered during chemotherapy is protective of ovarian function and fertility. ⋯ Based on the available studies, GnRHa appear to improve ovarian function and the ability to achieve pregnancy following chemotherapy. Several randomized trials are underway to define the role and mechanism of GnRHa in ovarian function preservation. In the meantime, premenopausal women facing chemotherapy should be counseled about ovarian preservation options, including the use of GnRHa therapy.
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Journal of women's health · Oct 2007
Meta AnalysisDuloxetine for the treatment of fibromyalgia in women: pooled results from two randomized, placebo-controlled clinical trials.
To assess the efficacy (in particular, in pain, functional impairment, and quality of life) and safety and tolerability (incidence of adverse events, discontinuation rates, changes in laboratory findings, and vital signs) of duloxetine in female patients with fibromyalgia. ⋯ The pooled results of these studies demonstrate that duloxetine is a safe and efficacious treatment for both the pain and functional impairment associated with fibromyalgia in female patients, while significantly improving quality of life.
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Journal of women's health · Dec 2004
Review Meta AnalysisAerobic exercise and lipids and lipoproteins in women: a meta-analysis of randomized controlled trials.
Cardiovascular disease (CVD) in women is the leading cause of mortality in the United States, and less than optimal lipid and lipoprotein levels are major risk factors for CVD. The purpose of this study was to use the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in women. ⋯ Aerobic exercise is efficacious for increasing HDL-C and decreasing TC, LDL-C, and TG in women.