Medicina clinica
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Mesenteric panniculitis (MP) is a rare disease characterized by chronic inflammation and fibrosis of the mesenteric adipose tissue. It is a benign disease that is influenced by many factors, mainly abdominal trauma and surgery. At present, the pathogenesis and clinical characteristics of MP are still not clear. ⋯ Medicine treatment is unnecessary for asymptomatic patients, and the curative effect of glucocorticoids is effective in patients with symptom. In the absence of severe intestinal obstruction, surgical treatment should not be considered. The purpose of this paper is to systematically introduce and summarize the epidemiology, etiology, histopathology, clinical manifestations, diagnosis, treatment and prognosis of MP, so as to improve the understanding of this disease.
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Even though a large number of antihypertensive drugs are suitable for hypertension treatment, some new therapeutic targets are recently under development. Most are focused in the treatment of resistant hypertension, added to the drugs currently available for treating such condition. ⋯ In addition, dual endothelin receptor antagonists or agonists of the NPR1 receptor, the main effector of natriuretic peptides are other new interesting therapeutic possibilities. In this paper, we review clinical data on the development of the most interesting molecules acting through these new therapeutic targets.
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Pheochromocytomas are rare neuroendocrine tumors that derive from the chromaffin cells of the adrenal medulla and secrete catecholamines. The measurement of plasma or fractionated urine metanephrines is the hormonal determination of choice for the biochemical diagnosis. Once the biochemical diagnosis is confirmed, the next step is the localization study. ⋯ Once the diagnostic study is completed, preoperative treatment with alpha blockers should be instituted at least 7-14 days before adrenalectomy. However, in low-risk patients, the omission of presurgical treatment could be considered if the surgery is performed in centers with experience and a strict monitoring of the patient is carried out during the perioperative period. This document offers a practical guide on the diagnosis and perioperative approach in patients with pheochromocytomas.