Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
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J Dtsch Dermatol Ges · Jun 2011
[S3-guidelines for the treatment of psoriasis vulgaris--methods report].
This methods report summarizes the methodology used to update the German Psoriasis Guidelines. ⋯ The field of psoriasis therapy is in constant transition. A lack of head to head trials makes direct comparisons still a challenging task. Continuous updating will be necessary to respond to the further changes expected in the field of psoriasis.
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J Dtsch Dermatol Ges · Apr 2011
Case ReportsSuspicious pigmented tumor in Mulvihill-Smith syndrome.
Mulvihill-Smith syndrome is a rare progeria-like disorder with characteristic findings including premature aging, short stature, pointed face and multiple melanocytic nevi. A young patient with this syndrome was referred to our department because of a pigmented tumor which was suspected to be a malignant melanoma.
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In addition to topical monotherapy for mild and systemic monotherapy for moderate to severe psoriasis, combination therapy plays an important role in daily practice. Although clinical trials almost exclusively evaluate monotherapy regimens, in real life psoriasis patients are usually treated with combination therapies. All combinations are used, topical/topical, topical/UV-light, topical/systemic or UV-light/systemic. ⋯ Data on a benefit-risk-assessment are much more sparse in medical literature as compared to monotherapies. We summarize current knowledge about the use of combination therapies in psoriasis on the basis of published literature in the form of a table to show which combinations are possible, useful or which can not be recommended. This provides a quick overview of available options.