Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992) · Nov 2020
Action of hormonal therapy in amyotrophic lateral sclerosis: a systematic review.
Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by muscle weakness, atrophy, fasciculations, and decreased reflexes due to upper and lower motor neurons death. It can be present in both sexes (55-65 years), but with predominance in males. However, in female patients, ALS presents its first symptoms when they are already postmenopausal, when then the incidence ratio of the disease is practically equal between the sexes, which leads to a probable involvement of sex hormones in the development and protection against ALS. ⋯ Only four articles matched our inclusion criteria. Postmenopausal women who used exogenous estrogen did not have the same protective factor as women still under the action of endogenous estrogen in the same age group. There was also no increase in the survival of these women.
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Rev Assoc Med Bras (1992) · Nov 2020
High-expression of LncRNA MAFG-AS1 is associated with the prognostic of patients with colorectal cancer.
Long noncoding RNAs (lncRNAs) have been proven to exhibit distinct functions on the convoluted processes of tumor developments. Some studies on the biological functions of lncRNA MAFG-AS1 (MAFG-AS1) in cancers revealed that they may serve as an oncogene in some kinds of tumors, including colorectal cancer (CRC). However, little is known about the role of MAFG-AS1 in the prognostic of CRC. ⋯ MAFG-AS1 can serve as a novel potential biomarker to predict CRC patients' survival time.
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Rev Assoc Med Bras (1992) · Nov 2020
Polymorphisms of the GSTT1 and GSTM1 genes in polycystic ovary syndrome.
This study aimed to investigate the deletion polymorphisms of the genes of the glutathione S-transferase family GSTT1 and GSTM1 in patients with Polycystic Ovarian Syndrome (PCOS), comparing them with a control population. ⋯ In the studied sample, the deletion polymorphisms of the GSTT1 and GSTM1 genes isolated are not associated with PCOS, but in combination, they may be implicated in the etiology of the condition.
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Rev Assoc Med Bras (1992) · Nov 2020
Effects of nasal aspiration by the Proetz® method in pediatric patients with sinusitis.
To characterize the effects of nasal aspiration with Proetz® in peak nasal inspiratory flow (PNIF) in pediatric sinusitis (PS) patients with nasal obstruction. ⋯ Nasal aspiration with the Proetz® method significantly improved the clinical condition of sinusitis patients with nasal obstruction according to the visual analogical scale, the PNIF, and the SNOT-22 questionnaire. No correlation between the VAS and the PNIF could be found. The study confirms the importance of non-pharmacological interventions in the treatment of sinusitis in children, thus resulting in an improvement in their quality of life.
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Rev Assoc Med Bras (1992) · Nov 2020
Development of personalized molds for neovagina creation by 3D printer.
Additive Manufacturing (AM), also known as Rapid Prototyping, is a set of production technologies used in the synthesis of a particular physical object by adding layers to form a part based on data generated by Computer-Aided Design (CAD) systems. These technologies are widely used to quickly create prototypes of products and tools for commercial purposes. Over time, it has also been integrated with other areas, such as healthcare, since these tools have allowed health professionals to assist in diagnoses, surgical planning, and synthesis of orthoses and prostheses for patient rehabilitation. To develop models for the construction of dilators for the treatment of vaginal agenesis. ⋯ The proposed procedure for the manufacture of dilators presented good results and technological feasibility, indicating that it can be a good solution for the production and customization of gynecological devices.