Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992) · Dec 2021
Changes in cardiac cells due to ticagrelor and enoxaparin in a rat ischemia/reperfusion model.
Studies on ischemia/reperfusion injury remain the focus of interest. Ticagrelor and enoxaparin, which are antiaggregant and anticoagulant drugs developed for use in many cardiovascular pathologies, are still included in many ischemia/reperfusion studies. Remarkably, their new protective effects, especially with regard to ticagrelor, continue to be reported in the current literature. The aim of this study was to evaluate the beneficial effects of ticagrelor and enoxaparin pretreatments on the rat heart with histological and immunohistochemical markers in an ischemia/reperfusion model. ⋯ As supported by histological findings in our study, ticagrelor and enoxaparin have protective properties for heart tissue in this ischemia/reperfusion injury model.
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Rev Assoc Med Bras (1992) · Dec 2021
ReviewHepatitis C virus eradication on glycemic control and insulin resistance.
To review data regarding the effects of hepatitis C virus eradication on glycemic control and insulin resistance. ⋯ Although there is a relationship between hepatitis C virus infection and the development of insulin resistance and type 2 diabetes mellitus and recent advances in research, it was observed that there is no consensus on improving insulin resistance and glycemic control after antiviral treatment, probably due to methodological differences between studies. However, it emphasizes the need to guide people diagnosed with hepatitis C, regarding changes in lifestyle, encouragement of multidisciplinary monitoring, and control of other risk factors.