Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992) · Jul 2021
Evaluation of progesterone receptor expression in low- and high-grade astrocytomas.
Gliomas are tumors originating from glial cells. Gliomas are the most common primary neoplasms of the central nervous system, with astrocytomas being the most prevalent glioma subtype. Progesterone regulates several reproductive processes, such as ovulation and sexual behavior, and influences neuronal excitability, learning, and the neoplastic proliferation of glial cells. Progesterone functions mainly by interacting with intracellular progesterone receptors to modify the expression of the genes involved in cell proliferation, angiogenesis, and epidermal growth factor production. As not many studies on the hormone receptors in glial tumors have been reported, the objective of this study was to evaluate the expression of these proteins in astrocytomas and to determine whether their expression levels vary according to the tumor grade. ⋯ Progesterone receptors are present in both low- and high-grade gliomas; however, there is no significant difference in the levels of progesterone receptor expression between the tumor grades.
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Rev Assoc Med Bras (1992) · Jul 2021
Observational StudySurvival outcome of pulmonary metastasectomy among the patients with colorectal cancers.
Pulmonary metastasectomy for the treatment of metastatic colorectal cancer is essential, but high ranked evidence of survival benefit is lacking. Here, we aimed to examine the prognostic factors after pulmonary metastasectomy in patients with colorectal cancer. ⋯ Pulmonary metastasectomy was associated with significantly long-time survival rates in mCRC (43 months of DFS and 55 months of OS). The second relapse occurred in 25 (75.7%) patients, with isolated lung metastases in nearly half of the patients (45.5%). Therefore, lung metastases in mCRC were unique and a multidisciplinary team including a thoracic surgeon should manage these patients.
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Rev Assoc Med Bras (1992) · Jul 2021
The timing of micro-TESE: what is the ideal age for male and female partner to bring a child to home?
The aim of this study was to analyze the results of microsurgical testicular sperm extraction (micro-TESE) and investigate the potential factors that may affect the successful sperm retrieval and timing of micro-TESE. ⋯ The fertility decreased by both male and female age and for men with NOA. The early visit to doctor seemed to have positive effect.
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Rev Assoc Med Bras (1992) · Jul 2021
An evaluation of the relationship between vitamin D level and CTRP-9, tumor necrosis factor-alpha, thiol-disulfide hemostasis in women.
Many chronic diseases such as malignancy, cardiovascular diseases, endothelial dysfunction, and autoimmune diseases, which have been shown to be related to vitamin D in various studies; have similar relations with CTRP-9, TNFα, and thiol-disulfide hemostasis. We aimed to contribute to the literature by evaluating the relationship between CTRP-9, TNFα, and thiol-disulfide hemostasis and vitamin D levels, which we thought may have some effects on the pathogenesis of vitamin D deficiency. ⋯ It was determined that vitamin D deficiency causes a significant decrease in CTRP-9 level and a significant increase in TNFα level, as well as an increase in thiol/disulfide hemostasis in favor of disulfide, which may be a risk factor for increased oxidative stress. We considered that these changes may play mediator roles for many chronic diseases and metabolic disorders that are increasing in frequency due to vitamin D deficiency.
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Rev Assoc Med Bras (1992) · Jul 2021
Epidemiological analysis of hysterectomies performed at the public health system in the largest Brazilian city.
To analyze the public data of hysterectomies performed in the only health system in the city of São Paulo between 2008 and 2018. ⋯ Despite the decrease in the number of hysterectomies over the 11-year study period in São Paulo, it remains in high demand mainly for the treatment of uterine leiomyomatosis. Laparoscopic hysterectomy has been gaining ground and showed a slightly upward trend with a shorter hospital stay. Laparoscopic and vaginal hysterectomy required less financial support from the health system than open surgery.