Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992) · Aug 2022
Vitamin C (Ascorbic acid) protects from neuropathy caused by cisplatin, through enhanced heat shock protein-70 and reduced oxidant effect.
We aimed to determine whether vitamin C has a protective effect on cisplatin-induced neuropathy in rats. ⋯ We demonstrated the ameliorated effects of vitamin C on cisplatin-induced neuropathy through increased heat shock protein-70, nerve growth factor levels, and reduced inflammatory and oxidant effects. The results are promising to improve the neurotoxic effects of cisplatin in cancer patients.