Revista da Associacao Medica Brasileira (1992)
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Rev Assoc Med Bras (1992) · Dec 2021
Evaluating causative agents, mortality factors, and laboratory data of hospital-acquired pneumonia patients.
In the recent years, the increase in death rates from nosocomial pneumonia draws attention. The aim of this study was to examine the causative agents and mortality factors of patients with pneumonia who were followed up in the chest diseases intensive care unit. ⋯ In the clinical approach to hospital-acquired pneumonia, in order to prevent mortalities, it is important to reveal whether the newly emerging symptoms and signs are related to pneumonia, to identify the causative pathogen, and to determine the severity of the disease.
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Rev Assoc Med Bras (1992) · Dec 2021
Inula graveolens induces selective cytotoxicity in glioblastoma and chronic leukemia cells.
Crude oil extracts, components of extracts, and ethanolic extracts of Inula graveolens possess various pharmacological activities on various cancer cells including antioxidative and antiproliferative effects. Aqueous extract of this species has not been investigated on the liquid malignancies and solid tumors with a high incidence of treatment refractoriness and poor survival outcomes such as glioblastoma and leukemia. Hence, the present study aimed to evaluate the cytotoxic efficiency of I. graveolens aqueous extracts on human glioblastoma multiforme and chronic myelogenous leukemia cell lines in comparison to non-cancerous primary rat cerebral cortex and human peripheral blood mononuclear cells. ⋯ The extracts of I. graveolens have anti-cancer potential on human glioblastoma multiforme and chronic myelogenous leukemia cell lines without causing oxidative stress.
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[This corrects the article doi: 10.1590/1806-9282.67. Suppl1.20200721].